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CDC's 2021 MMWR additional states that in between January and June 2020, ninety two.7% of benzodiazepine-included deaths also associated opioids and 66.seven% included illicitly created fentanyl. It's popular that The mix of benzodiazepines with opioids significantly boosts the possible for lethality. Etizolam, flualprazolam, clonazolam, flubromazolam, and diclazepam are benzodiazepine substances just lately discovered over the illicit drug marketplace in the United States. The abuse of etizolam, flualprazolam, clonazolam, flubromazolam, and diclazepam has actually been linked to several fatalities recently in the United States. The constructive identification of those 5 substances in publish-mortem cases is a serious concern to the public safety. In addition, law enforcement data reveal which the substances at problem below have important presence in the United States illicit drug sector. In gentle in the law enforcement encounters and fatalities affiliated with the abuse of etizolam, flualprazolam, clonazolam, flubromazolam, and diclazepam these substances pose an imminent hazard to general public protection.